uhambo A Journey of Hope to Prevent HIV

The finding of the HVTN 702 Uhambo study is that the HVTN 702 vaccine is safe but not effective.


From 3 February 2020, we are no longer giving study vaccinations in HVTN 702 Uhambo, but still continuing follow up visits.


The study team and funders are grateful to all the HVTN 702 Uhambo participants for their time and effort to be part of the study. We appreciate the support we have received from political, research and community leaders in South Africa.


Different efforts to find an HIV vaccine are being pursued in South Africa and globally.


What is a vaccine study?

A vaccine teaches the body’s immune system to prevent a particular infection or fight a specific disease. Your immune system protects you from disease. To develop a vaccine, researchers need to test it in people. A vaccine study tests whether study vaccines are safe (do not cause health problems) and if people’s immune systems respond to the study vaccines. A vaccine study can also be used to find out if vaccines prevent or fight a specific infection or disease. It takes many vaccine studies to produce a safe, effective vaccine.

How will the health and rights of participants be protected?

Protecting the health and respecting the rights of participants are top priorities for everyone in the HVTN. Clinic staff will provide potential participants with adequate information about the study products and procedures, the possible risks and benefits of participating, and the rights they would have as a participant. A person is free to say yes or no about whether or not to join the study.

During the study, the clinic staff will regularly monitor participants to make sure the study injections are not causing any health problems. The clinic staff will also ask participants about any social problems they may experience from being in the study, and will help to resolve or address them.

There are other groups involved in protecting participants’ rights and well-being. Research clinics located near you will be able to provide you with more information in greater detail on these groups if you are interested.